Detection and Separation of Circulating Tumor Cells Using Magnetic Fluorescent Nanoparticles.
A novel core-shell magnetic fluorescent nanoparticle (FR@Z-pTA NPs) is developed by integrating an Fe3O4 magnetic core with a ZIF-8 shell and tannic acid coating to preserve cell viability and improve downstream analytical reliability, opening new avenues for the clinical implementation of CTC-based liquid biopsy.