Detection and Separation of Circulating Tumor Cells Using Magnetic Fluorescent Nanoparticles.

Shuiling Chen Yu-Wei Zhou Shao-Bing Zhou Xia Liu Jianwen Hou

2026 · Methods in molecular biology · Vol 2999, pp. 1-12 · 0 citations

Medicine

TL;DR

A novel core-shell magnetic fluorescent nanoparticle (FR@Z-pTA NPs) is developed by integrating an Fe3O4 magnetic core with a ZIF-8 shell and tannic acid coating to preserve cell viability and improve downstream analytical reliability, opening new avenues for the clinical implementation of CTC-based liquid biopsy.

DOI PubMed Semantic Scholar

View source

Similar papers

Review Sep 2026

Translational optical and electrochemical biosensing strategies for liquid biopsy in triple-negative breast Cancer: advances, challenges, and clinical implementation.

This review systematically correlates TNBC biomarkers with optimal sensing technologies, emphasizing how biomolecular properties affect sensor selection and performance and emphasizes future integration of biosensors with CTC-derived organoids, microfluidics, AI, and multiplexed detection to enable portable, clinically...

Karim G. Mohammed, M. Abdelgawad, Mohamed S. Attia · Clinica chimica acta; intern... · 0 citations

Review Open access 2026

Advances in nanotechnology for early cancer diagnosis: emerging nanoplatforms and multimodal imaging approaches.

Nanotechnology has revolutionized the field of cancer diagnosis, by enabling the development of innovative platforms for diagnosis that offer the potential to identify malignancies at an early stage, and they possess an unprecedented degree of sensitivity and specificity. This review focuses on the combination of nanot...

Yu-Xin Mao, M. Jamil, Dian-Hui Yang · American Journal of Cancer R... · 0 citations

Review Open access Aug 2026

Nanotechnology in Prostate Cancer: PSMA-Targeted Nanoplatforms, TME-Responsive Therapy, Immunomodulation, and Clinical Translation Challenges

Abstract The field of nanotechnology has demonstrated considerable potential in the diagnosis and treatment of prostate cancer, particularly through the use of prostate-specific membrane antigen (PSMA)-targeted platforms and tumor microenvironment (TME)-responsive systems. In the context of diagnosis, nanoparticle-base...

Wen-Jian Li · International Journal of Nan... · 0 citations

Aug 2026

Sensitive and Reproducible SERS Profiling of Tumor-Derived EVs via Uniform Microfluidic Nanobowl Arrays for Pancreatic Cancer Management.

A microfluidic SERS platform integrating plasmonic nanobowl arrays that simultaneously achieve a high enhancement factor and signal reproducibility and provides a promising tool for EV-based precision oncology.

Ruoke Wang, Ai-Peng Chen, Yu-Qing Wang et al. · Nano letters (Print) · 0 citations

Review Open access Aug 2026

Exosome-Based Liquid Biopsy in Biliary Tract Cancer: Nanotechnology-Enabled Strategies and Future Perspectives

A comprehensive overview of recent advancements in nanotechnology-enabled platforms designed to overcome technical challenges in achieving high-purity isolation and ultrasensitive detection in complex biological matrices, such as blood and bile is provided.

Yonghyun Choi, Jih-Yuk Yang, Jiwon Kim et al. · International Journal of Nan... · 0 citations

Open access Aug 2026

Peptide-functionalized magnetic nanobeads for EpCAM-targeted CTC isolation and immunotherapy efficacy evaluation in liver cancer.

Primary liver cancer lacks robust biomarkers for anti-PD-1/PD-L1 therapy. Methods: We engineered peptide-functionalized magnetic nanobeads (Pep@MNPs) for high-efficiency, EpCAM-dependent capture of circulating tumor cells (CTCs). This nanotechnology-based platform enabled a precise fluorescence quantitative system (cTP...

Xuejie Li, Shan Tian, Linyang Fan et al. · Talanta: The International J... · 0 citations