Author

Xiang-Jun Song

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Open access Sep 2026

Outer membrane vesicles secreted by avian pathogenic Escherichia coli promote intracellular survival in macrophages and systemic infection by regulating mitophagy through the MSTRG.11745.1/gga-miR-15b-5p/TNFAIP3 axis

Avian pathogenic Escherichia coli (APEC) is a major extraintestinal pathogen responsible for severe systemic infections in poultry. It evades the immune system and establishes persistent infection by hijacking macrophages as its primary site of intracellular survival. During the pathogenic process, outer membrane vesic...

Jia-Yin Gao, Zhe Li, Tong-Tong Cui et al. · Poultry Science · 0 citations

Sep 2026

The Hcp2b protein of APEC induces defective autophagy in HD11 cells by causing lysosomal dysfunction.

Proteomic analysis demonstrated Hcp2b impairs lysosomes, blocking autophagy, and Hcp2b elicits incomplete autophagy, characterized by blocked autophagic flux.

Ya-Qin Tian, Li-Ting Lu, Shu-Hui Wang et al. · Avian Pathology · 0 citations

Jul 2026

YgeP, a global regulator within the ETT2 pathogenicity island, coordinates motility-biofilm balance and negatively controls serum resistance in avian pathogenic Escherichia coli.

YgeP plays a central role in APEC pathogenesis by balancing two infection strategies: motility-mediated dissemination and colonization, and biofilm-mediated attachment and tolerance, and negatively regulates key virulence traits during the early stages of infection.

Weiyang Su, Zhe Li, Siqi Feng et al. · Veterinary Microbiology · 0 citations