The Hcp2b protein of APEC induces defective autophagy in HD11 cells by causing lysosomal dysfunction.

ITCH‐Mediated Ubiquitination and Degradation of THBS1: A Key Mechanism for Enhancing Mitochondrial Biogenesis and Alleviating Mouse Skeletal Muscle Atrophy

Itchy E3 ubiquitin‐protein ligase modulates mitochondria, and thrombospondin 1 positively regulates muscle atrophy, but their roles in muscle atrophy are unclear.

UBE2N flips the switch on for mitophagy and off for MASH

Autophagy reshapes plant hormone signaling.

Recent breakthroughs in autophagy highlight it as a vital pathway, beyond the ubiquitin-proteasome system and the endosomal pathway, in plant hormone signal transduction, where it selectively targets key transcription factors for vacuolar turnover. Here, we review and discuss the emerging interplay between autophagy an...

Inhibition of USP2 suppresses pathological pexophagy and rescues PEX1-deficient peroxisome biogenesis disorder

Dear Editor , Peroxisome biogenesis disorders (PBDs) are ultrarare, life-limiting inherited diseases in which functional peroxisomes are pathologically lost, driving progressive multisystem failure dominated by neurological involvement. 1 Clinically, PBDs are encompassed within the Zellweger spectrum disorders (ZSDs)

A selective inhibitor reveals roles for LONP1 in mitochondrial proteostasis and OXPHOS dependencies

PZL-26 targets LONP1 with nanomolar potency and on-target cellular activity, revealing OXPHOS and mitochondrial gene expression as key survival dependencies.

Targeting CH25H restores p62-mediated α-synuclein clearance.

Astrocytes remove extracellular α-synuclein aggregates through p62-dependent autophagy, yet the factors limiting this defense remain unclear. Zhang and colleagues recently identified cholesterol 25-hydroxylase as an inducible negative regulator of p62-mediated clearance. Genetic suppression or a p62-derived decoy pepti...