Pirfenidone Lung Distribution Amplified in Idiopathic Pulmonary Fibrosis: Roles of tight junction disruption and drug transporter dysregulation.
It is suggested that IPF pathogenesis creates a permissive microenvironment for PFD through simultaneous enhancement of paracellular permeability and active cellular uptake through simultaneous enhancement of paracellular permeability and active cellular uptake.
Xiao-Ting Gu, Chao-Yue Zheng, Bo Li et al.
· European Journal of Pharmace... · 0 citations