While transcriptomic profiling has become routine, identifying the TFs underlying these expression patterns remains a major challenge, particularly for crops and non-model species lacking efficient transformation systems. To connect expression correlations with candidate regulatory mechanisms, we developed PURE (Plant...
Chuan-Shun Li, Le-Yi Yang, Kan-De Lin et al.· Plant Communications· 0 citations
ProRB is introduced, a unified sequence-based framework that jointly estimates protein–RNA binding affinity, predicts binding interfaces in proteins and RNAs, and generates protein-binding RNA sequences from protein sequences that provides a scalable unified model for decoding the protein–RNA interaction and engineerin...
An RNA design approach, AlignIF, that leverages multiple structure alignment with cross-graph modeling and carefully hand-designed features to capture evolutionarily conserved structural patterns at the structural level, facilitating RNA sequence design outperforms existing state-of-the-art methods in test sets.
Sheng-Fan Wang, Jun Wang, Xiao-Jian Liu et al.· Nature Computational Science· 2 citations· ⚡1
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