Author

Xiao-Long Liu

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Open access Sep 2026

Glutamine sequestration promotes tumor growth and immune evasion through elevation of arginine methylation in hepatocellular carcinoma

Mechanisms underlying the immunosuppressive microenvironment in hepatocellular carcinoma (HCC) extend beyond immune checkpoints to include metabolic competition. Here, we identify a metabolic evasion pathway driven by SLC1A5 overexpression, which enables HCC cells to sequester glutamine from the tumor microenvironmen...

Jingjing Nian, Zi-Ran Wang, Shi-Yi Chen et al. · Cell Death & Disease · 0 citations

Open access Aug 2026

Urinary Proteomics Enables Non-Invasive and Longitudinal Monitoring of Tumor Burden Dynamics and Early Recurrence in HCC.

PURPOSE To develop a non-invasive, urine-based approach for dynamic monitoring of tumor burden and early detection of recurrence in hepatocellular carcinoma (HCC), addressing the limited sensitivity of conventional serum biomarkers such as AFP and DCP, particularly for minimal residual disease (MRD) assessment. METHO...

Xiao-Hua Xing, En Hu, Lei Song et al. · Molecular & Cellular Proteom... · 0 citations

Open access Jul 2026

Biomimetic PD-1-Functionalized Immunostimulatory Nanomedicine Enables STING Activation and Durable Antitumor Immunity in Hepatocellular Carcinoma

Clinical cohort analyses identify stimulator of interferon genes (STING) signaling as a key determinant of immune responsiveness in hepatocellular carcinoma (HCC), providing a data-driven rationale for nanomedicine design. A carrier-free coordination nanomedicine co-assembles MSA-2 and indocyanine green to couple photo...

Yanbing Cao, Xin-Yi Lin, Bingchen Wu et al. · Nano-Micro Letters · 0 citations