Xiao-Xue Li

Biomimetic mycobacterial dual spatiotemporal targeting induces trained immunity for tuberculosis photothermal immunotherapy and relapse prevention.

These findings show that TDN + AIE@MM integrates physical sterilisation, immunosuppression reversal, and durable immune memory via dual spatiotemporal targeting, effectively addressing the three core challenges in TB therapy, namely delivery barriers, immune evasion, and relapse risk, and offering a promising strategy...