Self-extending DNA recording with stochastic and programmed writing
Recording cellular histories requires new information to accumulate without erasing earlier records. Here we introduce Infinite Printer, a CRISPR recording architecture that couples self-extension to regeneration of a writable terminal context. A self-targeting prime-editing guide RNA (stpegRNA) directs repeat extensio...
Zhihui Zhang, Yingyi Li, Yifang Peng et al.
· bioRxiv (Cold Spring Harbor... · 0 citations