Targeting the Ero1α-PDI oxidative protein folding pathway as a broad-spectrum strategy against coronavirus.
The rapid mutation of the SARS-CoV-2 spike (S) protein promotes immune evasion and challenges current therapeutics. However, its cysteine/disulfide bond pattern is highly conserved across coronaviruses and essential for its structure and function. Here, we demonstrate that the folding and maturation of the S protein is...
Xin-Qian Li, Ping Liu, Xi'e Wang et al.
· Redox Biology · 0 citations