Author

Xin-Yu Cao

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Open access Aug 2026

Diosgenin enhances transplanted human oligodendrocyte precursor cell-mediated myelination in preterm white matter injury by inhibiting matrix metalloproteinase-9–driven TGF-β/Smad2/3 signaling

Findings uncover a previously unrecognized MMP-9–TGFβ–Smad2/3 axis controlling hOPC-mediated myelin repair, and establish diosgenin as a promising adjunct therapeutic agent for cell-based strategies against PWMI and other white matter disorders.

Qing-Wei Lai, Xiaoyu Yao, Lin-Kang Bai et al. · Neurotherapeutics · 0 citations

Jul 2026

Structure-Based Drug Design of Novel Indazole/Indolinone-Based Biaryl Derivatives as Oral IRAK4 Inhibitors for the Treatment of Inflammatory Diseases.

Compound 43 exhibited potent molecular and cellular IRAK4 inhibitory activities as well as in vivo anti-inflammatory activities in both LPS-induced acute inflammation and collagen-induced arthritis models alongside favorable pharmacokinetic properties, indicating that compound 43 is a valuable lead compound for further...

Zhen-Wei Zhang, Xue Wang, Xuan Luo et al. · Journal of Medicinal Chemist... · 0 citations