Structure-Based Drug Design of Novel Indazole/Indolinone-Based Biaryl Derivatives as Oral IRAK4 Inhibitors for the Treatment of Inflammatory Diseases.

Design, synthesis and anti-inflammatory evaluation of arylamide-modified pyrrolo[2,3-d]pyrimidine derivatives against acute lung injury.

Treatment with compound B19 significantly alleviated pulmonary inflammation and edema, attenuated inflammatory cell infiltration, and markedly decreased pro-inflammatory cytokine levels in bronchoalveolar lavage fluid and provides a solid foundation for the further development of pyrrolo[2,3-d]pyrimidine-based anti-inf...

Computational Evaluation of New 2-Aminothiazole Derivatives as Anti-Inflammatory Agents

Inflammation is a biological process implicated in numerous chronic diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Dysregulated inflammatory signaling is primarily mediated by Tumor Necrosis Factor-alpha (TNF-α), which is identified as a major contributor to the progression of these...

Synthesis, Pharmacological Evaluation, Molecular Docking, and In Silico ADMET Profiling of Novel Ibuprofen–Chalcone Hybrids as Potent Anti-Inflammatory Agents

Design, synthesis, and molecular modeling of quinoline-linked diphenylpyrazoles as multitarget EGFR, VEGFR-2, and COX-2 inhibitors with anticancer, anti-inflammatory and apoptosis-inducing properties.

A new series of quinoline-diphenylpyrazole hybrids were rationally designed, synthesized, and biologically evaluated as potential EGFR/VEGFR-2/COX-2 inhibitors, supporting the proposed hybrid design strategy.

Discovery of oxazole-capped 4-phenoxypiperidine CSF1R type II inhibitors with potent in vivo anti-rheumatoid arthritis activity.

Colony-stimulating factor 1 receptor (CSF-1R) is a key target for regulating macrophage function and mediating the inflammatory response. Blocking CSF-1/CSF-1R signaling pathway and its downstream AKT cascade can effectively inhibit the release of downstream proinflammatory cytokines, which provides a promising therape...

Novel quinoline-2-one derivatives as potent receptor Interacting protein kinase 1 (RIPK1) inhibitors with therapeutic activities for acute respiratory distress syndrome

As a key regulator of cellular programmed necrosis and inflammatory signaling pathways, receptor interacting protein kinase 1 (RIPK1) is closely linked to the pathogenesis and progression of acute respiratory distress syndrome (ARDS). In this study, building on hits identified from docking simulations, a series of qu...