Aug 2026
Maternal sleep deprivation reshapes offspring hippocampal development through a Trem2-centered microglial program revealed by single-nucleus and spatial transcriptomics.
The findings identify maternal sleep deprivation as an early-life insult that programs a Trem2-centred microglial axis shaping hippocampal circuits and long-lasting cognitive and behavioral alterations, and suggest microglial Trem2 as a candidate target for mitigating neuropsychiatric risk associated with adverse sleep...
Xiaobin Wu, Liuqing Yang, Yepeng Fan et al.
· Molecular Psychiatry · 0 citations