Maternal sleep deprivation reshapes offspring hippocampal development through a Trem2-centered microglial program revealed by single-nucleus and spatial transcriptomics.

Xiaobin Wu Liuqing Yang Yepeng Fan Xiaohuan Li Xiuyu Shi Chunfang Dai Yayan Pang Jiaojiao Wang Yupeng Cun Zhi-Fang Dong

Aug 2026 · Molecular Psychiatry · 0 citations · 106 references

Medicine

TL;DR

The findings identify maternal sleep deprivation as an early-life insult that programs a Trem2-centred microglial axis shaping hippocampal circuits and long-lasting cognitive and behavioral alterations, and suggest microglial Trem2 as a candidate target for mitigating neuropsychiatric risk associated with adverse sleep in pregnancy.

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