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Review Open access Sep 2026

Drug Delivery With Metal–Organic Frameworks

More than 100 000 metal–organic frameworks (MOFs) have already been experimentally reported, and new structures continue to emerge every year. While they were originally developed as porous materials for gas storage and separation, MOFs attracted attention early on for biomedical applications due to their ability to...

Nathalie W. Tarabay, Alexander S. Evtushenko, M. A. Kiapi et al. · 0 citations
Open access Sep 2026

Hierarchically porous metal–organic frameworks with red topology for hydrogen and methane storage

The construction of highly porous metal–organic frameworks with complex topologies requires precise matching between linker conformation and node connectivity. Here we report the reticular design and synthesis of CU-6-M (M = Fe or Cr), assembled from conformationally adaptive diphenylethynyl linkers and six-connect...

Xu Chen, L. H. Wee, Mohammad Reza Alizadeh Kiapi et al. · 0 citations
#small language model Open access Sep 2026

Flow-Guided Chemical Language Modeling for Linker Design in Reticular Chemistry

Reticular chemistry has enabled the synthesis of tens of thousands of metal–organic frameworks (MOFs), yet the discovery of new materials still relies largely on intuition-driven linker design and iterative experimentation. As a result, researchers explore only a small fraction of the vast chemical space accessible to...

Dhruv Menon, Vivek Singh, Xu Chen et al. · 0 citations

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