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Author

Xue-Si Chen

2 papers indexed here

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Sep 2026

Loss of LRRK2 Protects Against Ox-LDL-Induced Endothelial Oxidative Damage Via NRF2.

This study investigated the role of LRRK2, a protein implicated in cancers but poorly understood in atherosclerosis, in oxidized low-density lipoprotein (Ox-LDL)-induced endothelial dysfunction. An in vitro model was established using HUVECs treated with Ox-LDL. Cell viability, apoptosis, reactive oxygen species (ROS)...

Ping-Feng Wang, Xue-Si Chen, Xiao-Yu Chen et al. · 0 citations
Review Sep 2026

Spatiotemporal Nanotherapy After Myocardial Infarction: Targeting the Inflammatory-to-reparative Transition With Extracellular Vesicles and Engineered Nanoparticles.

This review evaluates how extracellular vesicles, cell-derived nanovesicles, and engineered nanoparticles can be matched to these changing biological requirements to demonstrate phase-dependent target availability, controlled exposure, target-cell cargo engagement, and reduced benefit or emerging harm with a deliberate...

Xue-Si Chen, Ying-Chun Bao, Qi-Jun Zhang · 0 citations

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