Loss of LRRK2 Protects Against Ox-LDL-Induced Endothelial Oxidative Damage Via NRF2.
This study investigated the role of LRRK2, a protein implicated in cancers but poorly understood in atherosclerosis, in oxidized low-density lipoprotein (Ox-LDL)-induced endothelial dysfunction. An in vitro model was established using HUVECs treated with Ox-LDL. Cell viability, apoptosis, reactive oxygen species (ROS)...