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Xuelian Zhang

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#gene editing Open access Oct 2026

Phylogenomic screening reveals idsA2 loss conferring nitroimidazole cross-resistance in Mycobacterium tuberculosis

Bicyclic nitroimidazoles, notably pretomanid and delamanid, represent cornerstone agents of WHO-recommended short-course BPaLM regimens for multidrug-resistant Mycobacterium tuberculosis (MDR-TB), yet clinical cross-resistance frequently emerges without canonical activating mutations. Here, to uncover non-canonical res...

Yu Zhang, Xin-Chang Chen, Shi-Yong Wang et al. · 0 citations

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