#gene editing
Oct 2026
Hybridization‐Mediated Reversible sgRNA Caging Enables Tumor‐Selective Gene Editing for Potentiating Antitumor Immunity via cGAS Demethylation
ABSTRACT Spatiotemporal precision remains a critical challenge against the gene editing technology used for disease treatment. We herein developed a tumor cell‐selective CRISPR/Cas9 gene editing system by introducing a complementary single‐stranded DNA (ssDNA) containing apurinic/apyrimidinic (AP) sites (AP‐ssDNA) alon...
Haoyu Zhang, Yajie Li, Yehan Wang et al.
· Angewandte Chemie · 0 citations