Findings show that the late phase of podocyte-driven CKD involves distributed protein-level remodelling, including an RNA-discordant increase in NR3C2 protein and a candidate plasma-protein-handling signature.
Koichi Ito, Masaki Watanabe, Koyuki Kawamoto et al.· The FEBS Journal· 0 citations
Abstract Background Stress-related psychiatric disorders, including depression, are closely associated with alterations in synaptic structure and function in higher-order cortical regions. Accumulating evidence suggests that mitochondrial dysfunction contributes to stress-induced synaptic pathology. However, how chroni...
H. Nagai, K. Ota, C. Numa et al.· International Journal of Neu...· 0 citations
Abstract Advances in mass spectrometry (MS)-based proteomics have enabled the large-scale characterization of posttranslational modifications (PTMs) through affinity-based enrichment. However, this technique introduces a bias towards selectively enrichable modifications, thus leaving oxidative modifications underexplor...
Hiromasa Mitsui, Yusei Okuda, R. Konno et al.· DNA Research· 0 citations
Integrative multi-omics analyses in EL4 T cells reveal unrecognized mechanisms of lipid metabolic adaptation and highlight a regulatory network that coordinates fatty acid uptake in response to impaired lipid synthesis.
Takeru Endo, T. Kanno, R. Konno et al.· Scientific Reports· 0 citations
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