Author

Yan-Tao Jiang

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Open access Aug 2026

XPO1-mediated TRIM21 nuclear export reprograms TREM2+ macrophage polarization by targeting IRF3 to augment anti-PD-1 efficacy in small cell lung cancer

An XPO1-TRIM21-TNFSF15 axis is defined that promotes the polarization of immunosuppressive TREM2+ macrophages, which ultimately orchestrates immune exclusion by impairing antigen presentation and enhances the efficacy of anti-PD1 immunotherapy in mice.

Qing-Wu Du, Ting-Ting Qin, Jing-Ya Wang et al. · Nature Communications · 0 citations

Open access Sep 2026

Integrated single-cell and bulk transcriptomic analysis reveals an epithelial cell-derived prognostic and immunotherapeutic signature with ADAM12 as a key functional regulator in non-small cell lung cancer

Highlights • Single-cell transcriptomics reveals epithelial heterogeneity shaping NSCLC immunity.• A 101-algorithm ML framework constructs a Prognostic and Immunotherapeutic Signature.• PIS stratifies NSCLC patients by prognosis and immune checkpoint blockade response.• ADAM12 inhibition enhances anti-PD-1 efficacy in...

Hai-Lin Liu, Jun-Jie Yu, Yan-Tao Jiang et al. · Translational Oncology · 0 citations