Open access
Jul 2026
A novel continuous-progression CKM model combined with multi-omics data integration identifies lipid metabolic drivers of disease progression
A progressive rat model of CKM syndrome is established by combining high-fat/high-sucrose exposure with adenine-induced renal stress, capturing temporal changes from early metabolic dysregulation to advanced multi-organ injury and highlights renal lipotoxic remodeling as a potential therapeutic target in CKM progressio...
Hai-Lun Ye, Ya-Ni Wang, Gang-Ao Li et al.
· Frontiers in Endocrinology · 0 citations