Astrocyte-Specific dsRNA–ADAR1 Signalling Links Innate Immunity to Complement Activation in Parkinson’s Disease
Background Dysregulated innate immune activation is a key feature of Parkinson’s disease (PD), but the upstream triggers and cell-type-specific mechanisms remain unclear. Double-stranded RNA (dsRNA) has emerged as a potential driver of innate immune responses. Adenosine deaminase acting on RNA 1 (ADAR1), particularly i...
Yang Liu, G. Halliday, Yu-Hong Fu
· bioRxiv · 0 citations