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Yang-Yi Li

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Open access Sep 2026

GMPS drives pancreatic cancer progression via suppressing DNA damage, STING activation and cellular senescence

Highlights • GMPS is a prognostic biomarker and therapeutic target in PDAC.• GMPS knockdown suppresses PDAC proliferation in organoids, and PDX models.• GMPS deficiency triggers DNA damage, G1 arrest and cellular senescence.• GMPS knockdown activates the STING‑TBK1 innate immune pathway.

Yang-Yi Li, Zi-Feng Zhang, Ding-Ru Li et al. · 0 citations

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