Open access
GMPS drives pancreatic cancer progression via suppressing DNA damage, STING activation and cellular senescence
Yang-Yi Li
Zi-Feng Zhang
Ding-Ru Li
Cong Zhou
Yue-Yue Chen
Chun-Bin Zhu
Jian-Hui Yang
Rong-Hua Tang
Wei Wang
Xian-Jun Yu
Jin Xu
Medicine
Abstract
Highlights • GMPS is a prognostic biomarker and therapeutic target in PDAC.• GMPS knockdown suppresses PDAC proliferation in organoids, and PDX models.• GMPS deficiency triggers DNA damage, G1 arrest and cellular senescence.• GMPS knockdown activates the STING‑TBK1 innate immune pathway.