Nucleotide co-delivery modulates intracellular fate of LNP-delivered mRNA to enhance translation
Messenger RNA (mRNA) therapeutics offer a versatile platform for protein production, but preserving mRNA during delivery remains a major challenge. Here, we report that co-delivery of nucleotides with lipid nanoparticle (LNP)-formulated mRNA significantly enhances translation efficiency across multiple cell types. Syst...
Xuanyu Li, Zhiliang Qin, Yao Chen et al.
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