Author

Yi-Di Sun

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Open access Jul 2026

CENO: A Genome-Scale World Model for Evolutionary Sequence Interpretation and Programmable Regulatory Design

CENO is introduced, a family of long-context generative genomic world models designed to preserve local DNA grammar while extending usable context to regulatory and chromatin scales and provides a genome-scale sequence world-model framework for sequence interpretation, evolutionary reasoning, gene-scale reconstruction and programmable regulatory sequence generation.

Mingqian Ma, Yucheng Wu, Xin Chen et al. · bioRxiv · 0 citations

Jul 2026

Full-length single-cell spatial transcriptomics reveals spatial and cell-type-specific transcript isoforms in the primate brain

Fullscope-seq resolved hundreds of major isoform switches across distinct brain regions and identified DTUs between superficial and deep cortical layers and showed substantial enrichment for neuropsychiatric disorder-associated genes.

Hengxin Liu, Yanhong Hong, Y. Zhang et al. · Nature Methods · 0 citations