Single-cell landscape reveals PLPP2 upregulation underlying radiotherapy resistance and immune microenvironment remodeling in pancreatic cancer
Highlights • Single-cell transcriptomic profiling of multicenter pancreatic cancer radiotherapy cohorts identified PLPP2 as a key driver of radiotherapy resistance and immune microenvironment remodeling.• Random forest model identified PLPP2 as an important marker for promoting malignant progression, immune dysregulati...