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Open access Sep 2026

De Novo Design and Structural Optimization of Mn(salen)‐Based Artificial Metalloenzymes for Asymmetric Sulfoxidation

ABSTRACT Artificial metalloenzymes (ArMs) exhibit exceptional selectivity, yet extending their reactivity beyond native cofactors remains a major challenge. While previous designs using native protein scaffolds to incorporate nonnative cofactors have been reported, de novo protein design enables tailored scaffolds that...

Jing-Xiang Wang, Yun-Ling Deng, Indrek Kalvet et al. · 0 citations
#protein folding Review Oct 2026

A retrospective on 30 years of using peroxidases to study fundamental components of heme enzyme structure–function relationships

This review traces roughly 30 years of peroxidase engineering, built on half a century of prior enzymology and structural biology, as a case study in translational biomimicry. Beginning with the earlier work that defined Compound I and Compound II, we follow how structural biology established the peroxidase fold, how m...

Aaron P. Ledray, Yi Lu · 0 citations

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