Template-dependent conformational remodeling induced by matched mutation sets in an artificial metalloenzyme.
An ensemble-based model in which pre-existing conformational organization shapes how the protein responds to the matched mutations is supported and stability-engineering mutations should be evaluated in the context of the parent ensemble is argued.
Shiqinrui Xu, Yi Yuan, Shuo-Cheng Wang et al.
· Physical Chemistry, Chemical... · 0 citations