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Yi-Yuan Zhang

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Review Open access Aug 2026

A simplified nomogram for predicting deep vein thrombosis: development in NHANES and retrospective single-center external validation

Abstract Background Deep vein thrombosis (DVT) is a major cardiovascular burden, and existing risk-stratification tools often rely on laboratory biomarkers, limiting their utility in primary care. We developed and externally validated a simplified, laboratory-free nomogram to predict DVT in community settings. Methods...

Zhenlin Gu, Yi-Yuan Zhang, Hongchao Zhu et al. · 0 citations
Open access Oct 2026

Mitochondrial YME1L Restrains GRP75-Dependent ISR Activation to Prevent Podocyte Senescence in Diabetic Kidney Disease.

ARTICLE HIGHLIGHTS Loss of YME1L promotes podocyte senescence in diabetic kidney disease. YME1L deficiency induces sustained maladaptive integrated stress response activation. YME1L interacts with and regulates mitochondrial GRP75 homeostasis. GRP75 accumulation drives persistent integrated stress response activation a...

Qian-Qian Yang, Yi-Yuan Zhang, Yao-Wu Zhang et al. · 0 citations
Review Open access Aug 2026

Alpha-ketoglutarate alleviates chronic kidney disease via mitochondrial protection, gut microbiota, and metabolite remodeling.

Chronic kidney disease (CKD) is a significant global health challenge, yet no effective pharmacological interventions exist for it. Alpha-ketoglutarate (AKG) is widely utilized in food and nutritional supplements, demonstrating anti-inflammatory, antioxidant, and gut barrier-protective properties. However, the therapeu...

Juan Xie, Hailun Li, Haijing Dou et al. · 0 citations

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