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Open access
Aug 2026
Abstract Background Deep vein thrombosis (DVT) is a major cardiovascular burden, and existing risk-stratification tools often rely on laboratory biomarkers, limiting their utility in primary care. We developed and externally validated a simplified, laboratory-free nomogram to predict DVT in community settings. Methods...
Zhenlin Gu, Yi-Yuan Zhang, Hongchao Zhu et al.
· Annals medicus · 0 citations
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Open access
Oct 2026
ARTICLE HIGHLIGHTS
Loss of YME1L promotes podocyte senescence in diabetic kidney disease. YME1L deficiency induces sustained maladaptive integrated stress response activation. YME1L interacts with and regulates mitochondrial GRP75 homeostasis. GRP75 accumulation drives persistent integrated stress response activation a...
Qian-Qian Yang, Yi-Yuan Zhang, Yao-Wu Zhang et al.
· Diabetes · 0 citations
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Review
Open access
Aug 2026
Chronic kidney disease (CKD) is a significant global health challenge, yet no effective pharmacological interventions exist for it. Alpha-ketoglutarate (AKG) is widely utilized in food and nutritional supplements, demonstrating anti-inflammatory, antioxidant, and gut barrier-protective properties. However, the therapeu...
Juan Xie, Hailun Li, Haijing Dou et al.
· Journal of Pharmaceutical an... · 0 citations
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