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Mitochondrial YME1L Restrains GRP75-Dependent ISR Activation to Prevent Podocyte Senescence in Diabetic Kidney Disease.

Qian-Qian Yang Yi-Yuan Zhang Yao-Wu Zhang Hui Zhang Li-Qin Zhang Xiao-Bo Zhang Yong Xu Qi-Jing Wu
Oct 2026 · Diabetes · 0 citations
Medicine

Abstract

ARTICLE HIGHLIGHTS Loss of YME1L promotes podocyte senescence in diabetic kidney disease. YME1L deficiency induces sustained maladaptive integrated stress response activation. YME1L interacts with and regulates mitochondrial GRP75 homeostasis. GRP75 accumulation drives persistent integrated stress response activation and mitochondrial dysfunction.

DOI PubMed Semantic Scholar
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