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Author

Yibei Xiao

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Sep 2026

Discovery of Potent and Selective VHL-Recruiting PROTAC Degraders Targeting EGFR with Improved Developability and Potent Anti-NSCLC Efficacy

D4 was orally bioavailable and blood−brain barrier penetrant and completely inhibited tumor growth in vivo after oral dosing and provides promising starting points for next-generation EGFR-directed therapy.

Xiang Ni, Mei-Xiu Li, Jing-Lin Tang et al. · 0 citations
#protein folding Sep 2026

Integrated AI-Driven Multi-Objective Optimization of Sulfamoylbenzamide-Based HBV Capsid Assembly Modulators: Discovery of 11B-6 with Superior Potency and Drug-like Properties

A multi-objective optimization workflow for the NVR 3-778 is reported by integrating structure-based fragment growing with systematic medicinal chemistry optimization, activity prediction, and multitask prediction of drug-like properties to highlight 11B-6 as a promising next-generation HBV CAM.

Shuo Wang, Miao-Chen Xu, Fei-Yue Ma et al. · 0 citations

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