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Ying-Jun Zhao

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Open access Sep 2026

TMEM59 regulates microglial Aβ phagocytosis in a TREM2‐dependent manner and acts as a potential therapeutic target for Aβ amyloidosis

Microglia‐mediated clearance of amyloid beta (Aβ) is crucial for mitigating Alzheimer's disease (AD) progression, yet the molecular regulators of microglial phagocytosis remain incompletely understood.

Jian Meng, Yong Wang, Jing-Hui Wang et al. · 0 citations
Review Open access Sep 2026

Therapeutic Targeting of Tauopathies: From Druggable Biology to Precision Intervention.

Tauopathies encompass a heterogeneous group of neurodegenerative disorders characterized by the transition of tau from a microtubule-stabilizing protein into pathogenic, seed-competent species. Increasing evidence has redefined tau from a descriptive pathological hallmark to a pharmacologically actionable target across...

Cheng-Jia Zhang, Jia-Liang Ma, Xin-Ruo Wu et al. · 0 citations

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