Open access
TMEM59 regulates microglial Aβ phagocytosis in a TREM2‐dependent manner and acts as a potential therapeutic target for Aβ amyloidosis
Jian Meng
Yong Wang
Jing-Hui Wang
Yi-Qing Chen
Zi-Hao Zhao
Zi-Qian Tang
Jing Cao
Xian Zhang
Hong Luo
Hui-Hui Li
Yi-Li Wu
Ying-Jun Zhao
Wei-Hong Song
Yun-Wu Zhang
Medicine
Abstract
Microglia‐mediated clearance of amyloid beta (Aβ) is crucial for mitigating Alzheimer's disease (AD) progression, yet the molecular regulators of microglial phagocytosis remain incompletely understood.