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Ying Zhu

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#protein folding Sep 2026

Myelin-Inspired 3D PEGylation of Framework Nucleic Acids Enables Simultaneous Long Circulation and Rapid Renal Clearance.

This work establishes spatial conformation as a programmable parameter for regulating nanoparticle biodistribution and clearance, thereby shifting the design paradigm from compositional adjustment to architectural control and opening avenues for targeted delivery, imaging, and immunotherapy.

Qian Chen, Fei Ding, Shuang-Ye Zhang et al. · 0 citations
Review Jul 2026

Innate Immunity of Framework Nucleic Acids.

This Account reviews efforts to develop framework nucleic acids (FNAs) as a platform with modulable innate immunostimulation for biomedical applications in live cells and in vivo, and envision FNAs as intelligent tools for precision immunomodulation, bridging nanoscale design with immunological outcomes to advance pers...

Lin-Jie Guo, Fei Zhou, Ying Zhu et al. · 0 citations
Open access Jul 2026

Direct Cytosolic Delivery of Amphiphilic Framework Nucleic Acids for RNA Interference.

A class of amphiphilic framework nucleic acids (ampFNAs) that enable direct cytosolic delivery involving energy-independent traversal of lipid membranes and establishes ampFNAs as a programmable, efficient, and biocompatible platform for the development of next‑generation smart nucleic acid delivery machines for precis...

Lixuan Lin, Kai Jiao, Biancheng Wei et al. · 0 citations

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