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Author

Yong Xu

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Open access Oct 2026

Mitochondrial YME1L Restrains GRP75-Dependent ISR Activation to Prevent Podocyte Senescence in Diabetic Kidney Disease.

ARTICLE HIGHLIGHTS Loss of YME1L promotes podocyte senescence in diabetic kidney disease. YME1L deficiency induces sustained maladaptive integrated stress response activation. YME1L interacts with and regulates mitochondrial GRP75 homeostasis. GRP75 accumulation drives persistent integrated stress response activation a...

Qian-Qian Yang, Yi-Yuan Zhang, Yao-Wu Zhang et al. · 0 citations

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