Author

Yoo-Ree Kim

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#gene editing Aug 2026

Atypical MDM2 p53 Regulation and Chemosensitivity Induced by Proximal PAS Deletion

Results suggest that MDM2 3’UTR elongation may trigger a non-canonical regulatory mechanism that bypasses the traditional MDM2-p53 interaction, and suggests that APA-mediated gene modulation can induce unforeseen compensatory survival pathways in cancer cells, necessitating further investigation into the broader functi...

Minseo Kim, Celine Yoon, Jaewan Jun et al. · bioRxiv · 0 citations