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Author

Yu-Chao Zhang

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Open access Jul 2026

Assembly and priming of the VPS4B AAA+ ATPase of the human ESCRT system

The cryo-electron microscopy structure of the full-length human VPS4B hexamer in six-membered helical “spiral staircase” states suggests a mechanism for substrate-dependent hexamerization and priming of VPS4 for its ESCRT-III remodeling activity.

James H. Hurley, Yu-Chao Zhang, Shuixia Tan et al. · 0 citations

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