The cGAS‐STING pathway is a pivotal therapeutic target for antitumor immunity, yet clinical translation of its small‐molecule agonists is hindered by poor tumor specificity, suboptimal pharmacokinetics, and systemic off‐target effects. Here, we report a nanocatalytic strategy based on a tumor microenvironment (TME)‐res...
ABSTRACT Inducing pyroptosis in tumor cells has emerged as a promising anticancer strategy. However, under sublethal oxidative stress, a considerable fraction of cancer cells evades pyroptosis and undergoes therapy‐induced senescence, which ultimately drives chronic inflammation and facilitates tumor relapse. Here, we...
Zi-Lu Chen, Kun Mei, Yan Yang et al.· Advancement of science· 0 citations
Whole tumor cell vaccines are uniquely positioned for personalized immunotherapy by presenting the full repertoire of tumor-associated antigens to counter tumor heterogeneity, yet their translation is persistently hindered by poor immunogenicity and the requirement for multiple administrations. Herein, we introduce a s...
Hong-Ze Ren, Qing-Ying Wu, Wei Yang et al.· Angewandte Chemie· 0 citations
A living bacterial hybrid reactor is developed by integrating Shewanella oneidensis MR-1 with Cu(II)-based zeolitic imidazolate frameworks to enable metabolism-guided and tumor-confined bioorthogonal catalysis, overcoming key limitations of conventional bioorthogonal catalysis and enabling precise, tumor-confined thera...
