A transdermal CRISPR/Cas9 strategy using biodegradable microneedles to target YB-1 in melanoma
Melanoma's aggressiveness and therapeutic resistance highlight the need for innovative strategies. This study developed a CRISPR/Cas9 ribonucleoprotein (RNP) system targeting the oncogenic YB-1 gene, combined with doxorubicin (DOX), delivered by chondroitin sulfate (CS)-based microneedles (MN) incorporating designed na...
Xiazhou Fu, Zhao-Yi Chen, Zi-Ru Zhang et al.
· Materials Today Bio · 0 citations