Author

Yu-Liang Dong

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Jul 2026

Full-length single-cell spatial transcriptomics reveals spatial and cell-type-specific transcript isoforms in the primate brain

Fullscope-seq resolved hundreds of major isoform switches across distinct brain regions and identified DTUs between superficial and deep cortical layers and showed substantial enrichment for neuropsychiatric disorder-associated genes.

Hengxin Liu, Yanhong Hong, Y. Zhang et al. · Nature Methods · 0 citations

Open access Aug 2026

Complete genome-derived metabolic interactions reveal the impact of gut ecology on human health.

This work leverage 1,150 complete genomes to construct genome-scale metabolic models, demonstrating that draft assemblies introduce systematic artifacts and omit critical transport functions, and connects genome completeness with microbial ecological organization and provides a framework for linking metabolic interactions to microbiome-associated disease.

Yu-He Gu, Haoyu Wang, Jin-Long Yang et al. · Cell Reports · 0 citations