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Author

Yuan Gao

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Open access Aug 2026

Negative allosteric regulation of protein arginine methyltransferase 1 (PRMT1) through half-of-sites reactivity

Mechanistic understanding of inter-subunit communication in PRMT1 oligomers is expanded and half-of-sites reactivity is identified as a previously unrecognized regulatory feature that may be leveraged for the development of PRMT1-selective allosteric inhibitors.

Vincent Rossi, Robert S. Wilson-Kovacs, Yuan Gao et al. · 0 citations
Open access Jul 2026

Elucidating the half-site reactivity mechanism of Salmonella enterica FraB deglycase using native mass spectrometry

This nMS-based workflow offers a broadly applicable framework for resolving the catalytic states and inter-site communication of oligomeric enzymes that are otherwise difficult to uncover by conventional structural methods.

Yuan Gao, Jamison D. Law, Venkat Gopalan et al. · 0 citations

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