Elucidate the structural role of helper lipids in modulating hepatic expression following repeated intravenous administration of mRNA-LNPs
Lipid nanoparticles (LNPs) are the most advanced non-viral platform for hepatic mRNA delivery, yet the functional role of helper phospholipids, particularly under repeated dosing regimens required for chronic protein replacement therapies, remains poorly understood. Here, we systematically investigated six helper phosp...
Jia-Hao Ge, Xiaochen Bo, Xinye Zhu et al.
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