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Author

Yueying Yang

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#protein folding Dataset Open access Oct 2026

Processed HepG2 drug-perturbation proteomics data for DeepHeal

This dataset supports the 18-profile HepG2 analysis in “DeepHeal: An interpretable proteomics-first framework for computational drug repurposing”. It contains supplied processed protein log2 fold changes versus DMSO, the corresponding 18 × 9,960 aligned feature matrix, Average-194 and SupCon-257 frozen consensus repres...

Disheng Feng, Jing Liang, Kexin Zhang et al. · 0 citations
#protein folding Oct 2026

A transferable perturbation proteomics framework for phenotype- 1 based annotation and antiproliferative potency scoring of antineoplastic agents

Although antineoplastic agents target diverse proteins, whether they converge on conserved cellular response states remains unclear. Here, we generate a TMTpro 18-plex quantitative proteomics atlas of 367 antineoplastic agents in HepG2 cells and identify recurrent drug response phenotypes (DRPs). The higher-order organ...

Jing Liang, Jundan Tian, Rui Zhang et al. · 0 citations

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