Author

Yujie Li

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Open access Mar 2026

The WalRK two-component system in Streptococcus pneumoniae ensures robustness of secondary wall polymer attachment

This study shows that the conserved capsule gene CpsA is not strictly required for capsule attachment but instead works together with other LytRIZCpsAIZPsr (LCP) ligases, however, it requires the essential WalRK signaling system to maintain cell envelope integrity.

J. Zik, Zeyu Fu, M. Price et al. · bioRxiv · 0 citations

Open access Jul 2026

The WalRK two-component system in Streptococcus pneumoniae ensures robustness of secondary wall polymer attachment

A strong negative genetic interaction is identified between the genes encoding the putative capsule ligase CpsA and the WalRK histidine kinase, a component of the WalRK two-component system regulating cell wall homeostasis, showing that the conserved capsule gene CpsA is not strictly required for capsule attachment but...

J. Zik, Zeyu Fu, M. Price et al. · mBio · 0 citations