Single-nucleotide genome editing uncovers the biological impact of rs16944 in the IL1B promoter
Interleukin-1β (IL-1β) exerts context-dependent effects in cancer immunity, promoting both inflammatory tumor progression and antitumor immune responses. The IL1B promoter single-nucleotide polymorphism rs16944 has been associated with poor prognosis in hepatocellular carcinoma, yet its functional impact on immune sign...
Yosuke Namba, Tsuyoshi Kobayashi, Keishi Hakoda et al.
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