Author

Yun-wu Zhang

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Open access Sep 2026

TMEM59 regulates microglial Aβ phagocytosis in a TREM2‐dependent manner and acts as a potential therapeutic target for Aβ amyloidosis

Microglia‐mediated clearance of amyloid beta (Aβ) is crucial for mitigating Alzheimer's disease (AD) progression, yet the molecular regulators of microglial phagocytosis remain incompletely understood.

Jian Meng, Yong Wang, Jing-Hui Wang et al. · Alzheimer's & Dementia · 0 citations

Jul 2026

MAPT-derived circTau6 induces tau pathogenesis and neurodegeneration by encoding Tau variants.

Findings identify circTau6/cTau4R as a post-transcriptional mechanism that modulates tauopathy and partially recapitulated molecular signatures observed in human tauopathic brains.

Guangtong Jiang, Dan-Ni Wang, Lin Shao et al. · Molecular Psychiatry · 0 citations