A full-thickness spatial transcriptomics atlas of medically refractory ulcerative colitis identifies niche signatures associated with biologic non-response
Ulcerative colitis (UC) is a chronic mucosal immune disorder in which 30-50% of patients fail biologic therapy, yet the full-thickness immune architecture of medically refractory disease and reliable tissue-level markers of treatment response remain undefined. Using 10x Visium HD spatial transcriptomics (16-...
Qing-Quan Bai, Run-Yang Li, Zheng-Jin Liu et al.
· Frontiers in Immunology · 0 citations