Germline-Somatic Interplay Shapes Molecular Divergence in Peripheral Nerve Sheath Tumors.
Peripheral nerve sheath tumors (PNSTs) arising in neurofibromatosis type 1 (NF1) show marked histological and clinical heterogeneity, ranging from benign to malignant PNSTs. Although germline NF1 variants underlie tumor predisposition, the mechanisms driving phenotypic and clinical heterogeneity remain incompletely def...