Author

Z. Zhao

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Open access Sep 2026

Multi-omics analyses reveal cellular responses to biosynthesis of the non-natural cofactor nicotinamide cytosine dinucleotide

The ubiquitous cofactors nicotinamide adenine dinucleotide (NAD) and its reduced form play pivotal roles in energy metabolism and redox homeostasis. Recently, an NAD analog nicotinamide cytosine dinucleotide (NCD) has emerged for selective energy transfer in vivo . However, the biological effects of NCD remain elus...

Xiao-Jia Guo, Qian Wang, Ting Liu et al. · Frontiers in Bioengineering... · 0 citations

Open access Aug 2026

Selective Redox Tuning Enables Potent Intracellular Reduction of Nicotinamide Cytosine Dinucleotide

The ubiquitous nicotinamide adenine dinucleotide (NAD) engages in diverse biological processes, leading to non-selective energy transfer toward target synthetic reactions. To achieve selective energy transfer in complex biological systems, we previously constructed artificial systems mediated by the non-natural cofacto...

Xiao-Jia Guo, Yan-Zhe Huang, Ying-Han Hu et al. · Biomolecules · 0 citations

Jul 2026

Engineering alanine dehydrogenase to favor nicotinamide cytosine dinucleotide for formate-driven alanine synthesis.

To bypass the availability limitation and metabolic crosstalk associated with native reduced nicotinamide adenine dinucleotide (NADH) pools in L-alanine production, a non-natural cofactor system may offer a compelling strategy to secure independent reducing power. Here, we engineered an alanine dehydrogenase (AlaDH) fr...

Ying-Han Hu, Xiao-Jia Guo, Xue-Ying Wang et al. · International Journal of Bio... · 0 citations